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VPG

Hi-Yield 2,4-D Selective Weed Killer

Hi-Yield 2,4-D Selective Weed Killer is a selective liquid herbicide that eliminates various types of broadleaf weeds and other noxious plants in lawns, ponds, pastures, and rangelands.

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Hi-Yield 2,4-D Selective Weed Killer Product Page
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09/26/25
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Hi-Yield 2,4-D Selective Weed Killer, manufactured by VPG, is an effective post-emergent herbicide that controls a select but vast group of broadleaf weeds and noxious plants in lawns, ponds, and other terrains.

This post-emergent herbicide contains the powerful active ingredient 2,4-D 11.84%, which can be used for selective weed control for hard-to-control weeds like dandelion. 2,4-D successfully kills biennial and perennial broadleaf weeds and woody plants with only two applications per year.

Hi-Yield 2,4-D Selective Weed Killer's active ingredient, 2,4-D, works well to kill or control a large number of broadleaf weeds and noxious plants such as poison ivy, blessed thistle, honeysuckle, stinging nettle, and many others. As a selective herbicide, it will target broadleaf weeds while leaving most turf grasses unharmed.

Tools Needed

For Hi-Yield 2,4-D Selective Weed Killer, use a hand-held sprayer, backpack sprayer, hose-end sprayer, or spray rig to treat a large area. You will want to use a handheld sprayer to better control the spray drift when applying it.

How to Use

Spraying 2,4-D Selective Weed Killer on Weeds

  • Step 1: Determine how much Hi-Yield 2,4-D Selective Weed Killer to use by measuring the square footage of the treatment area. Do this by measuring the length and width of the treatment area in feet, then multiplying them together (length X width = square feet). To find acreage, divide the square footage by one acre (square footage / 43,560 sq. ft. = acre). In established pastures, rangelands, ornamental turf, and non-crop areas, use 1 gallon of Hi-Yield 2,4-D Selective Weed Killer in 15 gallons of water per acre. For small pasture and rangeland areas, use 3 to 4 fl. oz. (6 to 8 Tablespoons) of product per 1-3 gallons of water per 1,000 sq. ft. Use 1 gallon of this product in 25 gallons of water per acre for aquatic weed control.
  • Step 2: Fill your sprayer with half the water, add the required amount of Hi-Yield 2,4-D Selective Weed Killer, and fill with the remaining half of the water. Close the sprayer tank lid and agitate the spray mixture evenly.
  • Step 3: Spray the targeted broadleaf weed or noxious plants until evenly coated with the spray mixture. Spray to the point of wet, not runoff. The product will only be applied twice a year. No reapplication is necessary until 30 days have at least passed after application.

Where to Use

Use Hi-Yield 2,4-D Selective Weed Killer on turf on residential and agricultural lawns and other non-crop areas such as established pastures, rangelands, ornamental turf (lawn, golf courses, cemeteries, parks, and other grass areas), non-crop areas (airfields, right-of-way, fencerows, roadsides, vacant lots, drainage ditch-banks and similar places), and aquatic weed control (floating and emergent weeds applied through surface application).

When to Use

This product can be used in the fall but mainly during warm weather. The spray mixture will be effective as long as temperatures are below 90 degrees Fahrenheit and there is no predicted rainfall. Apply on calm days when wind speeds are low to minimize drift.

Safety Information

Hi-Yield 2,4-D is safe to use around children and pets when applied according to the product label instructions. Always wear the appropriate personal protective equipment (PPE) before mixing and applying this product.

Water applications may require local and state authorities' communication and approval, either through a letter of agreement or the issue of special permits, before a spray mixture is applied to a body of water.

Do not allow people or pets to enter the treated area until 48 hours have passed after application. 

Special considerations

Adding oil, a wetting agent, or another surfactant to the spray may increase Hi-Yield 2,4-D Selective Weed Killer's effectiveness on weeds but also may reduce selectivity to crops, resulting in crop damage.

AvailabilityOnline
Restricted UseNo
Shipping Restrictions1 Gallon: AK, CA, CT, HI, RI, SC, TX, VT, WA
32 Ounce: AK, CA, CT, HI, RI, SC, VT, WA
16 Ounce: AK, CA, CT, HI, RI, SC, VT, WA
BrandVPG
Keith's Pro Tips"Remember to control the spray drift when applying Hi-Yield 2,4-D Selective Weed Killer. Applying on warm days when wind speeds are low will help increase the product's effectiveness on your targeted broadleaf weeds and noxious plants."
Product DrawbacksDo not excessively apply Hi-Yield 2,4-D Selective Weed Killer to soil. If repeatedly applied it will keep turf/plants from growing. Refer to label as use/state restrictions apply.
Target PestsAlder, American Lotus, Arrowhead, Artichoke, Aster, Austrian fieldcress, Beggartick, Biden, Bindweed, Bitterweeds, Bitter Winter Cress, Blessed Thistle, Blue Lettuce, Box Elder, Broomweed, Buckhorn, Bull Thistle, Bulrush, Burdock, Bur Ragweed, Buttercup, Canada Thistle, Carpetweed, Catnip, Chickweed, Chicory, Cockle, Cocklebur, Coffee Bean, Coffeeweed, Common Sowthistle, Creeping Jenny, Croton, Curly Indigo, Dandelion, Dock, Dogbane, Duckweed, Elderberry, Fleabane (Daisy), Flixweed, Florida Pusley, Frenchweed, Galinsoga, Goatsbeard, Goldenrod, Ground Ivy, Gumweed, Healall, Hemp, Henbit, Hoary Cress, Honeysuckle, Horsetail, Indigo, Indiana Mallow, Ironweed, Jewelweed, Jimsonweed, Kochia, Knotweed, Lambsquarter, Locoweed, Lupine, Mallow, Marshelder, Mexican Weed, Morningglory, Musk Thistle, Mustard, Nettle, Nutgrass, Orange Hawkweed, Parrotfeather, Parsnip, Pennycress, Pennywort, Peppergrass, Pepperweed, Pigweed, Plantains, Poison Hemlock, Poison Ivy, Pokeweed, Poorjoe, Povertyweed, Prickly Lettuce, Primrose, Puncturevine, Purslane, Ragweed, Rush, Russian Thistle, Sagebrush, St. Johnswort, Shepherdspurse, Sicklepod, Smartweed, Sneezeweed, Southern Wild Rose, Sowthistle, Spanishneedle, Spatterdock, Stinging Nettle, Stinkweed, Sumac, Sunflower, Sweet Clover, Tarweed, Thistles, Toadflax, Tumbleweed, Velvetleaf, Vervain, Vetch, Virginia Creeper, Water Hyacinth, Water Lily, Water Plantain, Water Primrose, Water Shield, Wild Carrot, Wild Garlic, Wild Lettuce, Wild Onion, Wild Radish, Wild Rape, Wild Strawberry, Wild Sweet Potato, Willow, Witchweed, Wormseed, Yellow Rocket
Application EquipmentBackpack Sprayer, Gloves, Hose End Sprayer, Pump Sprayer, Respirator Mask, Spray Rig
Application MethodsBroadcast Spray, Spot Treatment
Active IngredientDimethylamine Salt of 2,4-Dichlorophenoxyacetic Acid 11.84%
Product TypeHerbicide
FormulationEmulsifiable Concentrate (EC)
Application RateIn established pastures, rangelands, ornamental turf, and non-crop areas use 1 gallon of Hi-Yield 2,4-D Selective Weed Killer in 15 gallons of water per acre. For small pasture and rangeland areas, use 3 to 4 fl. oz. (6 to 8 Tablespoons) of product per 1-3 gallons of water per 1,000 sq. ft. For aquatic weed control, use 1 gallon of this product in 25 gallons of water per acre.
Shelf LifeHi-Yield 2,4-D Selective Weed Killer will last up to 3 years when stored in secured storage building away from other open containers, fertilizer, seeds or other pesticides. Keep container tightly sealed when not in use to prohibit the product from expiring sooner.
Yield1 gallon of Hi-Yield 2,4-D Selective Weed Killer can treat up to 1 acre.
Use SitesOutdoors
Time to KillHi-Yield 2,4-D Selective Weed Killer will take up to 7 days to eliminate weeds.
Comparable Products2,4-D Amine Selective Post-Emergent Herbicide
Use Caution WithBentgrass, St Augustine
Incompatible Home SidingBrick, Hardie Plank, Stone Veneer, Stucco, Wood, Vinyl
EPA Registration #228-238-7401
More Information
Restricted Use No
Shipping Restrictions AK, CA, CT, HI, RI, SC, WA
Availability Online
Signal Word CAUTION
Keith's Pro Tip "Remember to control the spray drift when applying Hi-Yield 2,4-D Selective Weed Killer. Applying on warm days when wind speeds are low will help increase the product's effectiveness on your targeted broadleaf weeds and noxious plants."
Target Pests Multi Arrowhead, Aster, Austrian Fieldcress, Beggarticks, Biden, Bindweed, Bitter Winter Cress, Bitterweed, Blessed Thistle, Blue Lettuce, Broomweed, Buckhorn, Bull Thistle, Bulrush, Bur Ragweed, Burdock, Buttercup, Canada Thistle, Carpetweed, Catnip, Chickweed, Cockle, Cocklebur, Coffeeweed, Common Sowthistle, Creeping Jenny, Curly Indigo, Dandelion, Dock, Dogbane, Fleabane Daisy , Flixweed, Florida Pusley, Frenchweed, Galinsoga, Goatsbeard, Gumweed, Healall, Hemp, Henbit, Hoary Cress, Honeysuckle, Horsetail, Indiana Mallow, Indigo, Ironweed, Jewelweed, Jimsonweed, Knotweed, Kochia, Lambsquarters, Locoweed, Lupine, Mallow, Marshelder, Mexicanweed, Morningglory, Musk Thistle, Nettle, Nutgrass, Orange Hawkweed, Parrotfeather, Parsnip, Pennycress, Pennywort, Peppergrass, Pepperweed, Pigweed, Plantain, Poison Hemlock, Poison Ivy, Pokeweed, Poorjoe, Poverty Weed, Prickly Lettuce, Primrose, Puncture Vine, Purslane, Ragweed, Rush, Russian Thistle, Sagebrush, Shepherdspurse, Sicklepod, Smartweed, Sneezeweed, Southern Wild Rose, Sowthistle, Spanishneedles, Spatterdock, St. Johnswort, Stinging Nettle, Stinkweed, Sunflower, Tarweed, Thistle, Toadflax, Tumbleweed, Velvetleaf, Vervain, Virginia Creeper, Wild Carrot, Wild Garlic, Wild Lettuce, Wild Onion, Wild Radish, Wild Rape, Wild Strawberry, Wild Sweet Potato, Willow, Witchweed, Wormseed, Yellow Rocket, Alder, Artichoke, Boxelder, Chicory, Coffee Bean, Croton, Elderberry, Goldenrod, Ground Ivy, Mustard, Sumac, Sweet Clover, Vetch, American Lotus, Duckweed, Water Hyacinth, Water Lily, Water Plantain, Water Primrose, Water Shield
Time to Kill Hi-Yield 2,4-D Selective Weed Killer will take up to 7 days to eliminate weeds.
Chemical Type Herbicide
Formulation Emulsifiable Concentrate (EC)
Application Methods Broadcast Spray, Spot Treatment
Product Drawbacks Do not excessively apply Hi-Yield 2,4-D Selective Weed Killer to soil. If repeatedly applied it will keep turf/plants from growing. Refer to label as use/state restrictions apply.
Active Ingredient Dimethylamine Salt of 2,4-Dichlorophenoxyacetic Acid 11.84%
Application Equipment Backpack Sprayer, Gloves, Hose End Sprayer, Pump Sprayer, Respirator Mask, Spray Rig
Mix Rate In established pastures, rangelands, ornamental turf, and non-crop areas use 1 gallon of Hi-Yield 2,4-D Selective Weed Killer in 15 gallons of water per acre. For small pasture and rangeland areas, use 3 to 4 fl. oz. (6 to 8 Tablespoons) of product per 1-3 gallons of water per 1,000 sq. ft. For aquatic weed control, use 1 gallon of this product in 25 gallons of water per acre.
Use Sites Outdoors
Yield 1 gallon of Hi-Yield 2,4-D Selective Weed Killer can treat up to 1 acre.
EPA Registration No. 228-238-7401
Shelf Life Hi-Yield 2,4-D Selective Weed Killer will last up to 3 years when stored in secured storage building away from other open containers, fertilizer, seeds or other pesticides. Keep container tightly sealed when not in use to prohibit the product from expiring sooner.
Comparable Products 2,4-D Amine Selective Post-Emergent Herbicide
Children or pets? No
Property Characteristics None

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