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For a long time, anticoagulants had been used to control rodent like rats and mice which had invaded buildings and households, but over time these rodents developed a resistance against anticoagulant formulas and were steadily becoming less effective. 

Rodenticide manufacturers tried to counter this resistance by developing what are called “second-generation anticoagulants” with the hopes that they would hasten up the killing process and reduce. Researchers and laboratories eventually appeared to find an alternative rodenticide which possessed many of the beneficial attributes of anticoagulants but featured a unique mode of action to improve the efficiency of the poison to kill rodents. One such product which was worked on to be a viable candidate is cholecalciferol (Vitamin D3).

Solutions Pest & Lawn proudly carried rodenticide products which contain the powerful active ingredient cholecalfciferol. On this page, you can learn more about chlorophacinone and why it works so effectively to kill even the toughest rodent infestations as well as shop the product we have in our inventory.

WHAT IS Cholecalciferol?

Cholecalciferol (Chemical name: C27H44O) is a form of vitamin D, also called vitamin D3. Vitamin D3 kills anticoagulant-resistant rats and mice yet substantially reduces the risk of secondary poisoning of non-target animals.  In it’s original form cholecalciferol is an amber crystalline solid. Cholecalciferol is practically insoluble in water, soluble in the usual organic solvents, and slightly soluble in vegetable oils. 

Cholecalciferol was first developed and registered in the 1980s by Bell Laboratories. In 1984, cholecalciferol was registered for use as a rodenticide. Cholecalciferol was a major ingredient in these rodenticides made by the Dutch manufacturer Phillips-Dunphar and Wisconsin-based Bell Laboratories, the Environmental Protection Agency explained in a report. This chemical compound has been used primarily against Norway rats, roof rats, and house mice. When approved for this use, its toxicology on humans or the environment had not been heavily researched. 

HOW DOES Cholecalciferol WORK?

Cholecalciferol is is an acute single feeding rodent bait. Cholecalciferol first enters the body via oral ingestion and first accumulates in the liver. Here, the first metabolic change begins. Major functions of Vitamin D in animal nutrition are known. Many critical reactions in the body require calcium. In addition to forming new bone, calcium is needed for the formation of egg shells, milk production, blood clotting, neuromuscular action and a host of other functions. Cholecalciferol compromises these functions

Vitamin D3 mobilizes the calcium from the bone matrix to plasma and death from hypercalcemia. After one lethal dosage, rodents will usually stop feeding due to rapid onset of symptoms.

View our selection of Cholecalciferol formulated products below. For more information about Cholecalciferol or other active ingredients in our rodenticides, please call us with your questions at 800-479-6583 or email us at askapro@solutionsstores.com


WHERE IS Cholecalciferol USED?

Cholecalciferol can successfully be used to control stubborn rodent infestations such as Norway rats, roof rats, mice, field rodents, opossums, and raccoons. It can be applied inside and outside of industrial buildings and homes, in outdoor alleys, port terminals, sewers, farmhouses, grain stores, factories, fields, and transport vehicles such as trains, ships, and aircraft.


In most areas, a tamper resistant bait station is required by law to avoid accidental poisoning of humans and unintended species.



Humans, livestock, dogs and other pets will be poisoned if they eat bait and between 100-200 gms of bait is fatal to humans. Treatment of cholecalciferol poisoning is difficult so preventing access to bait is critical. The risk of non-target poisoning is reduced by using cholecalciferol baits in bait stations or other dispensers on trees or posts where they are less accessible to non-target species than baits on the ground.


We highly recommend when applying Cholecalciferol based rodenticide baits to the area to use a tamper resistant bait station which we also sell. Products which contain this active ingredient should be handled carefully and as directed.


If you are using a product containing cholecalciferol, the following tips should be heeded:


• Ensure bait is correctly placed.

• Exclude children, livestock, dogs and other pets from areas where baits are in use.

• Retrieve and bury uneaten bait.

• Clean up any spilled baits. to contaminate food or water supplies. In case of accidental ingestion, call the Center for Poison Control and a doctor immediately. If accidently ingested, it is required to be prolonged treatment with Vitamin K1 is required to recover from poisonings.


Learn more about how to get rid of rodents on our rodent control page.

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