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In earlier years. rodent poisons contained warfarin, an anticoagulant designed to prevent the clotting of blood for rats and mice, eventually leading to death via internal bleeding. For a while it was an effective active ingredient, that is, until rats and mice started to develop a resistance against such rodenticides. 

It was then that rodenticide manufacturers went back to the drawing board and developed what are called “second-generation anticoagulants” to speed up the killing process and lessen rodent resistance. One such rodenticide active ingredient which has shown success in eliminating rodents is Chlorophacinone. 

Solutions Pest & Lawn is proud to carry products containing this powerful active ingredient. On this page, you can learn more about chlorophacinone and why it works so effectively to kill even the toughest rodent infestations as well as shop the product we have in our inventory.

What Is Chlorophacinone?

Chlorophacinone (Chemical Name:2-(alpha-4-chlorophenyl-a-phenylacetyl)-1,3-indandione) is a multiple-dose anticoagulant rodenticide. This means that they generally require that an animal eat multiple doses of the bait over several days for death to occur. It is known as a superwarfarin and was developed to improve upon the warfarin formula, making it more effective.

Chlorophacinone was first registered for use in the mid-1960s by Lipha SA at concentrations of 0.05% in baits and 0.2% in tracking dust. Chlorophacinone in its pure form is a yellow crystalline solid that is very soluble in acetone, ethanol, ethyl acetate, but is only somewhat soluble in water. It is quite stable and resistant to weathering. 

Chlorophacinone does not induce bait-shyness and is compatible with cereals, fruits, roots, and other potential bait substances. Its acute LD50 in R. norvegicus is about 20.5 mg/kg, which is less toxic than warfarin, but it has a stronger initial effect on rats and mice. For control of rodent populations, a prolonged feeding period is needed. Chlorophacinone may not be effective against warfarin-resistant rodents.

How Does Chlorophacinone Work?

Chlorophacinone is a second generation anticoagulant that has a mode of action which prevents the clotting of blood by decreasing Vitamin K levels in the blood. By preventing the body from recycling vitamin K which is needed to clot blood. Once an infected rodent runs out of vitamin K they ultimately die by bleeding to death internally. It can take several days for the body’s stores of vitamin K to be exhausted.  Anticoagulants were originally discovered as naturally occurring in moldy sweet clover hay in the 1940s. Related compounds were later synthesized by pharmaceutical companies to produce a range of second generation anticoagulants that are more potent. 

Once Chlorophacinone is ingested, Chlorophacinone absorbs into the liver and interferes with the synthesis of vitamin K-dependent clotting factors. Eventually the blood ceases to clot and permeates the artery walls. The rodent dies of multiple causes related to blood loss. Vitamin K1 works as an antidote for accidental ingestion, and prolonged treatment is required because it has a long half life (up to several months). Chlorophacinone eliminates rats in a matter of days.

View our selection of Chlorophacinone formulated products below. For more information about Chlorophacinone or other active ingredients in our rodenticides, please call us with your questions at 800-479-6583 or email us at askapro@solutionsstores.com


Where is Chlorophacinone used?

Chlorophacinone can successfully be used to control stubborn rodent infestations such as Norway rats, roof rats, mice, field rodents, opossums, and raccoons. It can be applied inside and outside of industrial buildings and homes, in outdoor alleys, port terminals, sewers, farmhouses, grain stores, factories, fields, and transport vehicles such as trains, ships, and aircraft. 


In most areas, a tamper resistant bait station is required by law to avoid accidental poisoning of humans and unintended species.


Is Chlorophacinone Safe To Use?

Chlorophacinone is safe to use with the proper safety precautions put into place. We highly recommend when applying bromadiolone based rodenticide baits to the area to use a tamper resistant bait station which we also sell. Chlorophacinone is highly toxic to humans, pets, and other wildlife including fish and birds. Products which contain this active ingredient should be handled carefully and as directed.


Chlorophacinone has a long shelf life, causing it to remain active for several months. Chlorophacinone should be kept away from children and pets. Gloves should be worn during treatment, make sure to wash hands after handling the bait, and avoid all contact with the mouth. Do not allow the bait to contaminate food or water supplies. In case of accidental ingestion, call the Center for Poison Control and a doctor immediately. If accidently ingested, it is required to be prolonged treatment with Vitamin K1 is required to recover from poisonings.


Learn more about how to get rid of rodents on our rodent control page.


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