• Call (800) 479-6583
  • Mon-Fri 8am-5pm
  • |
  • Sat 9am-5pm


Diphacinone is a main active ingredient used in a variety of rodenticide bait products for rodent control. Unlike most rodenticides, which are slow acting when it comes to delivering the lethal dosage, diphacinone has the ability to kill rodents quicker, usually within a day of the initial feeding.

Solutions Pest & Lawn is proud to carry products containing the active ingredient diphacinone . On this page, we will give you an overview about diphacinone and why it works so effectively to kill even the rat and mouse infestations. You can also shop and browse the diphacinone based products we have in stock.

What is Diphacinone?

Diphacinone (Chemical name: 2-diphenylacetyl-1,3-indandione) is an anticoagulant rodenticide first introduced by Vesicol Chemical Corp. and the Upjohn Co. It has been produced and used primarily in the United States as a 0.005% dry or liquid rodenticide bait. The pure form of diphacinone is a yellow powder that is very soluble in chloroform, toluene, xylene, and acetone, but only somewhat soluble in water. It will decompose in water due to sunlight. As a second-generation anticoagulant rodenticides, it is marketed to have efficacy against a number of target pest species.

Diphacinone was introduced in the early 1950s and was the first anticoagulant to require only one dose to kill rates. In most cases, however, two or three feedings are necessary with death occurring in 5-7 days.

How Diphacinone Works

Diphacinone is a second generation anticoagulant that has a mode of action which prevents the clotting of blood by decreasing Vitamin K levels in the blood. By preventing the body from recycling vitamin K which is needed to clot blood. Once an infected rodent runs out of vitamin K they ultimately die by bleeding to death internally. It can take several days for the body’s stores of vitamin K to be exhausted.  Anticoagulants were originally discovered as naturally occurring in moldy sweet clover hay in the 1940s. Related compounds were later synthesized by pharmaceutical companies to produce a range of second generation anticoagulants that are more potent. 

Once diphacinone is ingested, diphacinone absorbs into the liver and interferes with the synthesis of vitamin K-dependent clotting factors. Eventually the blood is unable to clot and permeates the artery walls. The rodent dies of multiple causes related to blood loss, such as internal hemmoraging. Vitamin K1 works as an antidote for accidental ingestion, and prolonged treatment is required because it has a long half life (up to several months). Diphacinone eliminates rats in a matter of days.

View our assortment of diphacinone formulated products below. For more information about diphacinone or other active ingredients in our pesticides, please call us with your questions at 800-479-6583 or email us at askapro@solutionsstores.com


Where is Diphacinone used?

Diphacinone can successfully be used to control stubborn rodent infestations such as Norway rats, roof rats, mice, field rodents, opossums, and raccoons. It can be applied inside and outside of industrial buildings and homes, in outdoor alleys, port terminals, sewers, farmhouses, grain stores, factories, fields, and transport vehicles such as trains, ships, and aircraft.


In most areas, a tamper resistant bait station is required by law to avoid accidental poisoning of humans and unintended species.


Is Diphacinone Safe To Use?

Diphacinone is safe to use with the proper safety precautions put into place. We highly recommend when applying diphacinone based rodenticide baits to the area to use a tamper resistant bait station which we also sell. Diphacinone is highly toxic to humans, pets, and other wildlife including fish and birds. Products which contain this active ingredient should be handled carefully and as directed.


Diphacinone should be kept away from children and pets. Gloves should be worn during application of the product, make sure to wash hands after handling the bait, and avoid all contact with the mouth. Do not allow the bait to contaminate food or water supplies. In case of accidental ingestion, call the Center for Poison Control and a doctor immediately. If accidently ingested, it is required to be prolonged treatment with Vitamin K1.

Contact Us