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Milestone Herbicide
Milestone Herbicide is a selective specialty herbicide that delivers sharp control of noxious weeds on ranges, pastures, and rights of way. It is also ideal for treating invasive brush, conifers, and hardwood species on professionally managed lands.
09/14/25
Milestone Herbicide, manufactured by DOW/CORTEVA, is a flexible post-emergent herbicide used to control susceptible weeds and certain woody plants, including invasive and noxious weeds, on ranges, pastures, industrial sites, and more.
What's great about Milestone is that it can control weeds while not damaging grasses or other native plants. Milestone is flexible in that it can be used in almost any treatment method such as broadcast, foliar, spot, cut-stump, basal, side-trim, dormant stem, or as a complement with grass herbicides for total vegetation control. If you are a land manager, this is a good product to have on your side.
Tools Needed
To use Milestone Herbicide, dilute the concentrate in a sprayer tank before use. A backpack sprayer will work for smaller applications, while a professional pesticide spray rig is recommended for larger applications.
How to Use
- Step 1: Determine how much Milestone Herbicide to use by measuring the square footage of the treatment area. To do this, measure the length and width of the treatment area in feet, then multiply them together (length X width = square footage). To get the acreage, divide the total square footage by one acre (square footage / 43,560 sq. ft. = acres). Milestone spot treatments should be applied at a rate of no more than 7 fl. oz. per acre in at least 20 gallons of water. The liquid amount varies depending on the height of the vegetation being sprayed. For example, you would need more liquid for taller vegetation and less liquid for vegetation that has been freshly cut before application. How much Milestone you need also depends upon what type of application you want to conduct and the size of the treatment area.
- Step 2: Fill the spray tank with half the required water, then add the appropriate amount of Milestone Herbicide. Add a selected surfactant as the label suggests and agitate the sprayer to ensure the solution is mixed well. You could also tank-mix Milestone with other selected herbicides (check the label for specifics)
- Step 3: Spray the application to targeted areas where weeds grow, preferably on a fan spray setting for uniform coverage. You could use the product as a ground broadcast, spot treatment, low-volume foliar application, or high-volume foliar application.
Where to Use
Milestone Herbicide can be used on rangeland, permanent grass pastures (including grasses grown for hay*), Conservation Reserve Program (CRP) acres, non-cropland areas including industrial sites, rights-of-way (such as roadsides, electric utility, and communication transmission lines, pipelines, and railroads), non-irrigation ditch banks, and natural areas.
When to Use
Use Milestone Herbicide when tough-to-control vegetation (unwanted trees, brush, woody plants) grows on a professionally managed worksite. For best results, apply Milestone when plants are actively growing, typically early in the summer.
Forbs can be seeded 90 days after a summer application as a dormant fall planting or the following spring. Do not use grasses treated with Milestone Herbicide for seed production in the preceding 18 months.
Safety Information
Milestone Herbicide is safe to use around children and pets when applied according to the product label instructions. Always wear the proper personal protective equipment (PPE) when mixing and applying this product.
Do not allow people or pets to enter treated areas until 48 hours after application.
Special Considerations
It is recommended that Milestone be applied with a high-quality non-ionic surfactant to enhance the product's effectiveness against conditions such as high temperature, low relative humidity, drought, dusty plant surfaces, and more mature plants.
Milestone Herbicide is intended for use by land management professionals. It is not intended for use by non-professional do-it-yourselfers on residential lands.
Availability | Online |
Restricted Use | No |
Shipping Restrictions | 2.5 Gallon: AK, CA, CT, HI, IN, MI, NY, OR, RI, SC, VT, WA 32 Ounce: AK, CA, CT, HI, IN, MI, NY, OR, RI, SC, VT, WA |
Brand | CORTEVA |
Keith's Pro Tips | "When using Milestone Herbicide as a spot treatment, you must use a well-calibrated sprayer to prevent misapplication." |
Product Drawbacks | Milestone Herbicide requires a non-ionic surfactant for best results. Not recommended for small applications. |
Target Pests | Milestone Herbicide controls the following: Absinith Wormwood, Annual Broomweed, Annual Lespedeza, Annual sowthistle, Artichoke Thistle, Bedstraw, Beggarticks, Bitter Sneezeweed, Black Henbane, Black Locust, Black Medic, Blessed Milk Thistle, Bristly Oxtongue, Bull Thistle, Camelthorn, Canada Thistle, Carolina Horsenettle, Chickweed, Chicory, Clover, Cocklebur, Common Burdock, Common Cat's ear, Common Ragweed, Common St.Johnswort, Common Sunflower, Common Yarrow, Crazyweed, Crwonvetch, Curly Dock, Cutleaf Evening Primrose, Diffuse Knapweed, Fiddleneck, Fireweed, Flax-leaf Fleabane, Giant Hogweed, Giant Ragweed, Hairy Buttercup, Hairy Fleabane, Henbit, Honey Locust, Horseweed, Indian Thistle, Japanese Bohemian Knotweeds, Japanese Stiltgrass, Knapweeds, Kudzu, Lady's Thumb, Lambsquarters, Locoweed, Malta Starthistle, Meadow Knapweed, Mimosa, Mullein, Musk Thistle, Orange Hawkweed, Oxeye Daisy, Panicle Willoweed, Pennsylvania Smartweed, Perennial Sowthistle, Plumeless Thistle, Povertyweed, Purple Cudweed, Purple Loosestrife, Purple Starthistle, Redbud, Rush Skeletonweed, Russian Knapweed, Russian Thistle, Scentless Chamomile, Scentless Mayweed, Scotch Thistle, Sicklepod, Silverleaf Nightshade, Spanishneedles, Spiny Amaranth, Spotted Knapweed, Squarrose Knapweed, Stinking Mayweed, Sulfur Cinquefoil, Swainson Pea, Tall Buttercup, Tall Ironweed, Tansy Ragwort, Teasel, Tree of Heaven, Tropic Croton, Tropical Soda Apple, Vetch, Western Ironweed, Western Ragweed, White Sweetclover, Wild Licorice, Wisteria, Wooly Distaff, Yellow Hawkweed, Yellow Stathistle, and Yellow Sweetclover. |
Application Equipment | Backpack Sprayer, Pump Sprayer, Spray Rig |
Application Methods | Basal Treatment, Broadcast Spray, Spot Treatment |
Active Ingredient | Triisopropanolammonium salt of 2-pyridine carboxylic acid, 4-amino-3,6-dichloro 40.6% |
Product Type | Herbicide |
Formulation | Emulsifiable Concentrate (EC) |
Application Rate | The mix rate for Milestone Herbicide varies depending on the problem weed and the area you are looking to treat. Make sure not to exceed 7 oz. of Milestone applications per acre per year. To prepare the spray, add about half the required amount of water in the spray tank. Then, with agitation, add the specified amount of Milestone and other registered tank mix herbicides. Finally, while continuing to agitate, add the rest of the water and additives such as surfactant. |
Shelf Life | Milestone Herbicide will last for 3 to 5 years when stored in a cool, dry place. |
Yield | A 32 ounce bottle of Milestone Herbicide can treat at least 8 acres of land when applied at a moderate rate of 4 oz per acre. |
Use Sites | Outdoors |
Time to Kill | Targeted plants should show signs of yellowing and death within a few days. Some more persistent plants may need reapplication after 14 days for best results. |
Comparable Products | Remedy Ultra Herbicide |
Incompatible Home Siding | Brick, Hardie Plank, Stone Veneer, Stucco, Wood, Vinyl |
EPA Registration # | 62719-519 |
Restricted Use | No |
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Shipping Restrictions | AK, CA, CT, HI, IN, MI, NY, OR, RI, SC, VT, WA |
Availability | Online |
Signal Word | CAUTION |
Keith's Pro Tip | "When using Milestone Herbicide as a spot treatment, you must use a well-calibrated sprayer to prevent misapplication." |
Target Pests Multi | Absinth Wormwood, Annual Broomweed, Annual Lespedeza, Annual Sowthistle, Artichoke Thistle, Bedstraw, Beggarticks, Bitter Sneezeweed, Black Henbane, Black Medic, Blessed Milk Thistle, Bohemian Knotweed, Bristly Oxtongue, Bull Thistle, Buttercup, Canada Thistle, Carolina Horsenettle, Catsear, Chickweed, Clover, Cocklebur, Common Burdock, Common Catsear, Common Ragweed, Common St. Johnswort, Common Sunflower, Common Yarrow, Crazyweed, Crown Vetch, Curly Dock, Cutleaf Evening Primrose, Diffuse Knapweed, Fiddleneck, Fireweed, Flax-Leaf Fleabane, Giant Hogweed, Giant Ragweed, Hairy Buttercup, Hairy Fleabane, Henbit, Horseweed/Marestail, Italian Thistle, Japanese Knotweed, Japanese Stiltgrass, Knapweed, Kudzu, Ladysthumb, Lambsquarters, Locoweed, Malta Star-Thistle, Meadow Knapweed, Mimosa, Mullein, Musk Thistle, Orange Hawkweed, Oxeye Daisy, Panicle Willoweed, Pennsylvania Smartweed, Perennial Sowthistle, Plumeless Thistle, Poverty Weed, Purple Cudweed, Purple Starthirstle, Redbud, Rush Skeletonweed, Russian Knapweed, Russian Thistle, Scentless Chamomile, Scentless Mayweed, Scotch Thistle, Sicklepod, Silverleaf Nightshade, Spanishneedles, Spiny Amaranth, Spotted Knapweed, Squarrose Knapweed, Stinking Mayweed, Swainson Pea, Tall Buttercup, Tall Ironweed, Tansy Ragwort, Teasel, Tropic Croton, Western Ironweed, Western Ragweed, White Sweet Clover, Wild Licorice, Wisteria, Woolly Distaff Thistle, Yellow Hawkweed, Yellow Starthistle, Yellow Sweetclover, Black Locust, Camelthorn, Chicory, Honey Locust, Purple Loosestrife, Sulfur Cinquefoil, Tree-of-Heaven, Tropical Soda Apple, Vetch |
Time to Kill | Targeted plants should show signs of yellowing and death within a few days. Some more persistent plants may need reapplication after 14 days for best results. |
Chemical Type | Herbicide |
Formulation | Emulsifiable Concentrate (EC) |
Application Methods | Basal Treatment, Broadcast Spray, Spot Treatment |
Product Drawbacks | Milestone Herbicide requires a non-ionic surfactant for best results. Not recommended for small applications. |
Active Ingredient | Triisopropanolammonium salt of 2-pyridine carboxylic acid, 4-amino-3,6-dichloro 40.6% |
Application Equipment | Backpack Sprayer, Pump Sprayer, Spray Rig |
Mix Rate | The mix rate for Milestone Herbicide varies depending on the problem weed and the area you are looking to treat. Make sure not to exceed 7 oz. of Milestone applications per acre per year. To prepare the spray, add about half the required amount of water in the spray tank. Then, with agitation, add the specified amount of Milestone and other registered tank mix herbicides. Finally, while continuing to agitate, add the rest of the water and additives such as surfactant. |
Use Sites | Outdoors |
Yield | A 32 ounce bottle of Milestone Herbicide can treat at least 8 acres of land when applied at a moderate rate of 4 oz per acre. |
EPA Registration No. | 62719-519 |
Shelf Life | Milestone Herbicide will last for 3 to 5 years when stored in a cool, dry place. |
Comparable Products | Remedy Ultra Herbicide |
Children or pets? | No |
Property Characteristics | None |
*Price does not include freight. We guarantee our rate plus shipping will be less than anyone else's price.