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QUALI-PRO

Prodiamine 4L Pre-Emergent Herbicide

Prodiamine 4L Herbicide is a pre-emergent herbicide ideal for controlling broadleaf and grassy weeds on turfgrasses, lawns, ornamentals, and more. Just one application can potentially provide control all season long.

As low as $218.14
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Prodiamine 4L (2.5gal) Product Page
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10/25/25
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Prodiamine 4L Herbicide, manufactured by Quali-Pro, is a pre-emergent herbicide that controls many common weeds, including carpetweed, crabgrass, and more.

As a pre-emergent herbicide, it will control the weeds before they emerge but will not kill present weeds that have already appeared. It has an active ingredient of Prodiamine 40.8%, which is ideal for controlling weeds on turfgrasses, sod farms, lawns, Christmas tree farms, and ornamentals. 

Prodiamine 4L Herbicide is an easy-to-mix product that is ideal for year-long season control and ensures that annual or perennial weeds and wildflower plantings are by creating a barrier on the top of the soil for up to 6 months.

Tools Needed:

You can use a pump sprayer, a backpack sprayer, or a hose-end sprayer. For a large-volume application, you can use a spraying rig.

How to Use:

Spraying Prodiamine on lawn

  • Step 1: Determine how much Prodiamine 4L Herbicide to use by measuring the square footage of the treatment area. Do this by measuring the length and width of the treatment area in feet, then multiplying them together (length X width = square footage). Depending on the weed you are trying to control and the turf type, the maximum application rate can range from 0.23 oz. to 1.1 fl. oz. per 1,000 sq. ft per calendar year. For large applications with a professional spray rig, the maximum rate can range from 21 lbs. to 48 fl. oz. per acre per calendar year. For example, if you wanted to apply Prodiamine on Bermudagrass and measure a 2,000 sq. ft. area for treatment, the rate is 0.5 to 1.1. fl. oz. per 1000 sq. ft., so you would need to mix 1 to 2 fl. oz. in 2 gallons of water to cover the entire area.
  • Step 2: Fill your sprayer halfway with water. Measure the required amount of product and add it to the sprayer. Fill your sprayer with the rest of the water, thoroughly agitate it, and you are ready to apply. The amount of Quali-Pro Prodiamine 4L to use depends upon the length of residual weed control desired (the higher the application rate, the longer the control), the turf species, and the maximum amount that can be applied to the turf species per calendar year.
  • Step 3: Apply the Prodiamine solution over the desired area, following the label instructions regarding your application method and the plants being applied to. Applications can vary depending on these factors, so reading the label beforehand is important to understand how to use the product properly.
  • Step 4: Reapply as needed, following label instructions regarding your application type. After use, thoroughly clean the sprayer by flushing the system with a detergent.

Where to Use:

Use Prodiamine 4L Herbicide on turfgrasses (excluding golf course putting greens), lawns and sod nurseries ornamentals, and Christmas tree farms.

When to Use:

This product is most commonly used as a soil application over established plants, so it may not be the best option for young plants. Refer to the label for proper application timings, which can vary depending on the climate, targeted weed, and application method.

Safety Information:

Prodiamine 4L Herbicide is safe to use around children and pets when applied according to the product label instructions. Always wear the proper personal protective equipment (PPE) when mixing and applying this product.

Keep people and pets out of the treated area until the product completely dries.

Special Considerations:

Apply Quali-Pro Prodiamine 4L as a single application or in sequential applications to control weeds germinating throughout the year. All applications must be made before target weeds germinate, or it will not be effective. Quali-Pro Prodiamine 4L will not control weeds that have already emerged.

AvailabilityOnline
Restricted UseNo
Shipping RestrictionsNo Restrictions
BrandQUALI-PRO
Keith's Pro Tips"Pre-emergent herbicides like Prodiamine 4L only control weeds that have not sprouted and will not kill weeds already in place. It may be helpful to pair a pre-emergent herbicide with an approved post-emergent herbicide to control both established weeds and prevent them from growing back."
Product DrawbacksYou need to maintain vigorous agitation in the spray tank before and during the application to ensure a well-mixed spray suspension
Target PestsAnnual Foxtails, Annual  Bluegrass, Barnyardgrass, Broadleaf Signalgrass, Browntop Panicum, Buttercup Oxalis, Carpetweed, Common Chickweed, Common Purslane, Common Vetch, Crowfootgrass, Fall Panicum, Florida Pusley, Florida Betony, Goosegrass, Henbit, Itchgrass, johnsongrass, Junglerice, Knotweed, Kochia, Lambsquarters, Large Crabgrass, Lovegrass, Mouseear Chickweed, Persian Speedwell, Pigweed, Prostrate Spurge, Rescuegrass, Shepherdspurse, Smooth Crabgrass, Spramgletop, Texas Panicum, Wandering Jew, Witchgrass, Woolly Cupgrass, and Yellow Woodsorrel.
Application EquipmentBackpack Sprayer, Pump Sprayer, Spray Rig
Application MethodsBroadcast Spray, Spot Treatment
Active IngredientProdiamine 40.8%
Product TypeHerbicide
FormulationSuspended Concentrate
Application RateApply Quali-Pro Prodiamine 4L in a minimum of 20 gallons/acre (0.5 oz/1000 sq ft) of carrier (water and/or fluid fertilizer) using a calibrated, low-pressure sprayer with 50-mesh or coarser screens. For more specific application rates please refer to the label.
Shelf LifeWhen stored according to the product label, Prodiamine 4L will last for up to 1 to 2 years. Store Prodiamine 4L in a cool, dry storage area using the original container.
YieldA 2.5 gallon container of Prodiamine 4L can yield nearly 128 finished gallons of product when using the 0.5 to 1.1 fl. oz. mix rate.
Use SitesOutdoors
Time to KillProdiamine 4L has to be applied to areas before targeted weeds have sprouted during the early stages of germination. It does not kill weeds, it stops seeds from growing. The residual effects will last for up to 6 months.
Comparable ProductsProdiamine 65 WDG (Barricade Herbicide)
Use Caution WithBentgrass
EPA Registration #53883-379
More Information
Restricted Use No
Shipping Restrictions AK, DC
Availability Online
Signal Word CAUTION
Keith's Pro Tip "Pre-emergent herbicides like Prodiamine 4L only control weeds that have not sprouted and will not kill weeds already in place. It may be helpful to pair a pre-emergent herbicide with an approved post-emergent herbicide to control both established weeds and prevent them from growing back."
Target Pests Multi Annual Bluegrass, Annual Foxtails, Barnyardgrass, Broadleaf Signalgrass, Browntop Panicum, Buttercup Oxalis, Carpetweed, Common Chickweed, Common Lambsquarters, Common Purslane, Common Vetch, Crowfootgrass, Fall Panicum, Florida Betony, Florida Pusley, Goosegrass, Henbit, Itchgrass, Junglerice, Knotweed, Kochia, Large Crabgrass, Lovegrasses, Mouseear Chickweed, Persian Speedwell, Pigweed, Prostrate Spurge, Rescuegrass, Seedling Johnsongrass, Shepherdspurse, Smooth Crabgrass, Sprangletop, Texas Panicum, Wandering Jew, Witchgrass, Woolly Cupgrass, Yellow_Woodsorrel
Time to Kill Prodiamine 4L has to be applied to areas before targeted weeds have sprouted during the early stages of germination. It does not kill weeds, it stops seeds from growing. The residual effects will last for up to 6 months.
Chemical Type Herbicide
Formulation Suspended Concentrate
Application Methods Broadcast Spray, Spot Treatment
Product Drawbacks You need to maintain vigorous agitation in the spray tank before and during the application to ensure a well-mixed spray suspension
Active Ingredient Prodiamine 40.8%
Application Equipment Backpack Sprayer, Pump Sprayer, Spray Rig
Mix Rate Apply Quali-Pro Prodiamine 4L in a minimum of 20 gallons/acre (0.5 oz/1000 sq ft) of carrier (water and/or fluid fertilizer) using a calibrated, low-pressure sprayer with 50-mesh or coarser screens. For more specific application rates please refer to the label.
Use Sites Outdoors
Yield A 2.5 gallon container of Prodiamine 4L can yield nearly 128 finished gallons of product when using the 0.5 to 1.1 fl. oz. mix rate.
EPA Registration No. 53883-379
Shelf Life When stored according to the product label, Prodiamine 4L will last for up to 1 to 2 years. Store Prodiamine 4L in a cool, dry storage area using the original container.
Comparable Products Prodiamine 65 WDG (Barricade Herbicide)
Children or pets? No
Property Characteristics None

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